Kufotokozera Kwachidule:
Nambala ya CAS: 1264-72-8
Molecular formula:2(C52H98N16O135 (H2SO4)
molekyulu kulemera: 2801.27
Chemical kapangidwe:
| Zambiri Zoyambira | |
| Dzina la malonda | Colistin sulphate |
| Gulu | Feed Grade |
| Maonekedwe | White kapena pafupifupi woyera, hygroscopic ufa |
| Kuyesa | 99% |
| Alumali moyo | zaka 2 |
| Kulongedza | 20kg/katoni 20kg/ng'oma |
| Mkhalidwe | Sungani pa -20 ℃ kwa chaka chimodzi (Ufa) |
Kufotokozera za mankhwala
Colistin ndi cyclic cationic decapeptide yolumikizidwa ndi unyolo wam'mbali wamafuta acid, ndi wa gulu la ma peptides opangidwa ndi mabakiteriya oletsa tizilombo toyambitsa matenda.Colistin sulfate ndi mankhwala a polypeptide omwe amaletsa mabakiteriya opanda gram pomanga ma lipopolysaccharides ndi phospholipids mu nembanemba ya cell ya mabakiteriya a gram-negative.
Colistin sulfate, yemwe amadziwikanso kuti colistin sulfate, Christian (Colistin), Polymyxin E(Polymyxin E), antiphytin, ufa woyera kapena pafupifupi woyera, wosanunkhiza, wonyezimira wowawa, wosungunuka mosavuta m'madzi, sungunuka pang'ono mu methanol, ethanol, pafupifupi osasungunuka mu acetone, ether, alkali yaulere yosungunuka pang'ono m'madzi.Wokhazikika mumtundu wa PH3-7.5.Mycolistin sulfate amapangidwa ndi Bacillus polymyxoides, omwe ali ndi mphamvu yolimbana ndi mabakiteriya a gram-negative.Amagwiritsidwa ntchito pochiza matenda a m'mimba omwe amayamba chifukwa cha mabakiteriya a gram-negative, ndipo amagwiritsidwa ntchito ngati chowonjezera cha chakudya chomwe chimalimbikitsa kukula.Kuphatikiza sulfadiazine zotsatira ndi bwino.
Ntchito ya mankhwala
Ma granules a Colistin sulphate amathandizira kukhazikika kwa potency mu chakudya ndikuwonetsa kusungunuka kwakukulu ngakhale amapangidwa popanda kugwiritsa ntchito chonyamulira chokwera mtengo kapena zida zapadera.Makamaka, colistin sulfate granules wopangidwa makamaka colistin sulfate ndi tinthu diameters wa 150 mpaka 1500m, yeniyeni malo 40 mpaka 500 cm2/g, nthawi yonyowa mphindi 5 kapena pansi ndi okhutira 10 % kapena pansi.
Pharmacodynamics
Colistin ndi polymyxin antibiotic wothandizira.Ma polymyxins ndi ma cationic polypeptides omwe amasokoneza nembanemba ya cell ya bakiteriya kudzera m'makina otsukira.Ndikukula kwa mankhwala ochepetsa poizoni, monga ma penicillin otalikirapo ndi cephalosporins, kugwiritsiridwa ntchito kwa parenteral polymyxin kunasiyidwa, kupatulapo kuchiza matenda am'mapapo osamva mankhwala ambiri kwa odwala omwe ali ndi cystic fibrosis.
