Kufotokozera Kwachidule:
Nambala ya CAS: 27164-46-1
Mapangidwe a maselo: C14H15N8NaO4S3
Kulemera kwa molekyulu: 478.5
Chemical kapangidwe:
| Zambiri Zoyambira | |
| Dzina la malonda | Cefazolin sodium mchere |
| CAS No. | 27164-46-1 |
| Maonekedwe | White to Off-White crystalline ufa |
| Gulu | Pharma kalasi |
| Kusungirako | Sungani pamalo amdima, mumlengalenga, 2-8 ° C |
| Shelf Life | zaka 2 |
| Kukhazikika | Chokhazikika, koma chikhoza kukhudzidwa ndi kutentha - sungani m'malo ozizira. Ikhoza kusinthika ikayatsidwa ndi kuwala - sungani mumdima. Zosagwirizana ndi ma oxidizing amphamvu. |
| Phukusi | 25kg / Drum |
Mafotokozedwe Akatundu
Semi synthetic antibiotic yokhala ndi cephalosporins mu molekyulu ya cephalosporins. Kutanthauziridwa ngati Xianfeng mycin. ndi β－Mankhwala opha maantibayotiki a Lactam, inde β- Zochokera ku 7-aminocephalosporanic acid (7-ACA) mu maantibayotiki a lactam zimakhala ndi njira zopha mabakiteriya zofanana. Mankhwala amtunduwu amatha kuwononga khoma la mabakiteriya ndikuwapha panthawi yobereka. Iwo ali amphamvu kusankha kwambiri mabakiteriya ndi pafupifupi palibe kawopsedwe anthu, ndi ubwino monga lonse antibacterial sipekitiramu, amphamvu antibacterial tingati, kukana penicillin michere, ndi zochepa thupi lawo siligwirizana poyerekeza penicillin. Chifukwa chake ndi mankhwala ofunikira omwe ali ndi mphamvu zambiri, kawopsedwe kakang'ono, komanso kugwiritsa ntchito kwambiri kuchipatala. Ma cephalosporins a m'badwo woyamba adapangidwa kale, okhala ndi mphamvu zolimbana ndi mabakiteriya poyerekeza ndi Chemicalbook, antibacterial spectrum, komanso zotsatira zabwino za anti Gram positive kuposa mabakiteriya a Gram negative. Wopangidwa ndi Staphylococcus aureus β- Lactamase ndi wokhazikika ndipo amatha kulepheretsa kupanga mabakiteriya omwe alibe ma β- Lactamase osakhazikika ndipo amatha kupangidwabe ndi ma bacteria ambiri a Gram negative β- Oonongeka ndi lactamase. Cefazolin sodium ndi semi synthetic m'badwo woyamba cephalosporin amene ali ndi antibacterial zotsatira motsutsana gram-positive ndi gram-negative mabakiteriya. Amagwiritsidwa ntchito kwambiri pa matenda a kupuma, dongosolo la urogenital, minofu yofewa ya khungu, mafupa ndi olowa, komanso thirakiti la biliary lomwe limayambitsidwa ndi mabakiteriya okhudzidwa, komanso matenda a endocarditis, sepsis, pharyngeal ndi khutu. Imakhala ndi mphamvu yolimbana ndi mabakiteriya omwe ali ndi gramu monga Staphylococcus aureus ndi Streptococcus (kupatula Enterococcus), ndipo imaposa yachiwiri ya m'badwo wachitatu wa cephalosporins.
Kugwiritsa Ntchito Chemical
Cefazolin (Ancef, Kefzol) ndi imodzi mwa mndandanda wa semisyntheticcephalosporins momwe ntchito ya C-3 acetoxy yasinthidwa ndi thiol-containing heterocycle-pano, 5-methyl-2-thio-1,3,4-thiadiazole. Mulinso gulu lachilendo la tetrazolylacetyl acylating. Cefazolin inatulutsidwa mu 1973 ngati mchere wa sodium wosungunuka m'madzi. Ndi mwachangu ndi parenteral makonzedwe.
Cefazolin imapereka milingo yapamwamba ya seramu, kuchedwa kwapang'onopang'ono, komanso theka la moyo wautali kuposa ma cephalosporins am'badwo woyamba. Ndi pafupifupi 75% ya mapuloteni omangidwa mu plasma, mtengo wapamwamba kuposa wa cephalosporins ambiri. Maphunziro oyambirira a m'mimba komanso azachipatala amasonyeza kuti cefazolin imakhala yogwira kwambiri motsutsana ndi gram-negative bacilli koma imakhala yochepa kwambiri motsutsana ndi gram-positive cocci kusiyana ndi cephalothin orcephaloridine. Kuchulukirachulukira kwa thrombophlebitis pambuyo pa jakisoni wamtsempha ndi ululu pamalo ojambulidwa ndi intramuscular jekeseni zikuwoneka kuti ndizotsika kwambiri mwa parenteralcephalosporins.
