Kufotokozera Kwachidule:
Nambala ya CAS: 472-15-1
Fomula ya mamolekyulu: C30H48O3
Kulemera kwa molekyulu:456.71
Chemical kapangidwe:
| Zambiri Zoyambira | |
| Dzina la malonda | Betulinic acid |
| Gulu | Pharma kalasi |
| Maonekedwe | Choyera kapena choyera |
| Kuyesa | 98% |
| Alumali moyo | zaka 2 |
| Kulongedza | 25kg / ng'oma |
| Mkhalidwe | Wokhazikika, koma sungani ozizira. Zosagwirizana ndi oxidizing amphamvu, calcium gluconate, barbiturates, magnesium sulfate, phenytoin, mavitamini a sodium gulu B. |
Kufotokozera
Betulinic acid (472-15-1) ndi Lupane triterpenoid yachilengedwe yochokera ku white birch tree (Betula pubescens). Imapangitsa apoptosis m'maselo osiyanasiyana.1 Imapangitsa kuti mitochondrial permeability transition transition pore itseguke.2 ?Imagwira ntchito ngati chemosensitizer ya mankhwala oletsa khansa ya m'matumbo a chemoresistant colon cancer cell lines.3 Cell permeable.
Gwiritsani ntchito
Betulinic Acid ndi pentacyclic triterpenoid yachilengedwe. Betulinic Acid imawonetsa anti-yotupa komanso anti-HIV ntchito. Betulinic Acid mosankha imapangitsa apoptosis m'maselo a chotupa mwa kuyambitsa mwachindunji njira ya mitochondrial ya apoptosis kudzera pa p53- ndi CD95-yodziyimira pawokha. Betulinic Acid imawonetsanso zochita za TGR5 agonist.
Betulinic acid (BetA) yakhala ikugwiritsidwa ntchito:
1.kuyesa zotsatira zake ngati antiviral wothandizira motsutsana ndi kachilombo ka Dengue (DENV).
2.monga sterol regulatory element-binding protein (SREBP) inhibitor kuti iwononge lipid metabolism ndi kuchuluka kwa maselo omveka bwino a renal cell carcinoma (ccRCC).
3.monga chithandizo choyesa mphamvu zake zotsutsana ndi chotupa kuti zikhale zogwira mtima komanso zoyesa kufa kwa maselo a apoptotic mumitundu ingapo ya myeloma.
Kafukufuku wa Anticancer
Pagululi ndi pentacyclic triterpene yotengedwa kuchokera ku mitundu ya Betula ndi Zizyphus, yomwe imawonetsa cytotoxicity yosankha motsutsana ndi maselo a melanoma (Shoeb2006). Zimapanga mitundu yowonjezereka ya okosijeni, imayambitsa MAPK cascade, inhibitstopoisomerase I, inhibits angiogenesis, modulates pro-growth transcriptionalactivators, modulates ntchito ya aminopeptidase-N, ndipo potero imayambitsasapoptosis m'maselo a khansa (Desai et al. 2008; Fulda 2008).
Ntchito Zachilengedwe
Natural triterpenoid yomwe imawonetsa anti-HIV ndi antitumor ntchito. Imapangitsa kuti pakhale mitundu yambiri ya okosijeni (ROS) ndikuyambitsa NF- κ B. Kuwonetsa TRG5 agonist ntchito (EC 50 = 1.04 μ M).
Zochita za Biochem/physiol
Betulinic acid, pentacyclic triterpene, mwa kusankha imapangitsa apoptosis m'maselo a chotupa mwa kuyambitsa mwachindunji njira ya mitochondrial ya apoptosis kudzera pa p53- ndi CD95-yodziyimira pawokha.
