Kufotokozera Kwachidule:
Nambala ya CAS: 1197-18-8
Mapangidwe a maselo: C8H15NO2
Kulemera kwa molekyulu: 157.21
Kapangidwe ka Chemical:
| Zambiri Zoyambira | |
| Dzina la malonda | Tranexamic Acid |
| Gulu | Zodzikongoletsera kalasi |
| Maonekedwe | White kapena pafupifupi woyera, crystalline ufa |
| Kuyesa | 99% |
| Alumali moyo | zaka 2 |
| Kulongedza | 25kg / ng'oma |
| Chemical Properties | Amasungunuka m'madzi komanso mu glacial acetic acid ndipo amasungunuka pang'ono mu ethanol ndipo samasungunuka mu etha. |
Kufotokozera
Tranexamic acid ndi yochokera ku aminomethylbenzoic acid, ndi mtundu wa antifibrinolytic mankhwala oletsa magazi. Njira ya hemostasis ya tranexamic acid ndi yofanana ndi aminocaproic acid ndi aminomethylbenzoic acid, koma zotsatira zake zimakhala zamphamvu. Mphamvu ndi 7 mpaka 10 nthawi za aminocaproic acid, 2 nthawi za aminomethylbenzoic acid, koma poizoni ndi wofanana.
Kapangidwe ka mankhwala a tranexamic acid ndi ofanana ndi lysine, kuletsa mpikisano wa plasmin choyambirira mu fibrin adsorption, kuteteza kutsegula kwawo, kuteteza mapuloteni a fiber kuti asawonongeke ndi plasmin ndi kupasuka, pamapeto pake amakwaniritsa hemostasis. Ntchito pa matenda pachimake kapena aakulu, localized kapena zokhudza zonse CHIKWANGWANI fibrinolytic hyperthyroidism chifukwa cha magazi, monga obstetric kukha magazi, aimpso kukha mwazi, kukha mwazi wa prostate hypertrophy, hemophilia, m`mapapo mwanga TB hemoptysis, m`mimba magazi, pambuyo opaleshoni chiwindi, mapapo. , ndulu ndi zina za viscera kukha magazi; Angagwiritsidwenso ntchito pa opaleshoni pamene magazi achilendo etc..
Clinical tranexamic acid imakhudza kwambiri matenda olumidwa ndi tizilombo, dermatitis ndi chikanga, purpura yosavuta, urticaria, urticaria yochita kupanga, kuphulika kwapoizoni ndi kuphulika. Komanso imakhala ndi zotsatira zina pa erythroderma, scleroderma, systemic lupus erythematosus (SLE), Erythema multiforme, shingles ndi alopecia areata. Chithandizo cha cholowa angioedema zotsatira ndi zabwino. Pochiza Chloasma, mankhwala wamba amagwira ntchito pafupifupi milungu itatu, yothandiza kwambiri masabata asanu, masiku 60. Kupatsidwa pakamwa Mlingo wa 0,25 ~ 0,5 g, tsiku 3 ~ 4 zina. Odwala ochepa amatha nseru, kutopa, pruritus, kusapeza bwino m'mimba, ndi kutsekula m'mimba zotsatira zoyipa zikatha.
Zizindikiro
Zosiyanasiyana magazi chifukwa pachimake kapena aakulu, localized kapena zokhudza zonse chachikulu hyperfibrinolysis; yachiwiri hyperfibrinolytic boma chifukwa kufalitsidwa intravascular coagulation. Nthawi zambiri musagwiritse ntchito mankhwalawa musanafike heparinization.
Kuvulala kapena kutulutsa magazi m'thupi ndi ziwalo zokhala ndi zoyambitsa zambiri za plasminogen monga prostate, urethra, mapapo, ubongo, chiberekero, adrenal glands, ndi chithokomiro.
Wotsutsa wa minofu plasminogen activator (t-PA), streptokinase, ndi urokinase.
Kutaya magazi kwa fibrinolytic chifukwa cha kutaya mimba kochita kupanga, kutulutsa koyambirira kwa placenta, kubadwa wakufa ndi amniotic fluid embolism; ndi kuwonjezeka kwa menorrhagia chifukwa cha pathological intrauterine fibrinolysis.
Cerebral neuropathy kukhetsa magazi pang'ono, monga kukha magazi kwa subarachnoid komanso kutulutsa magazi m'mitsempha, zotsatira za Amstat mumtunduwu ndizabwinoko kuposa za anti-fibrinolytics. Chisamaliro chapadera chiyenera kuperekedwa ku chiopsezo cha edema ya ubongo kapena cerebral infarction.Kwa odwala kwambiri omwe ali ndi zizindikiro za opaleshoni, mankhwalawa angagwiritsidwe ntchito ngati mankhwala othandizira.
Pochiza cholowa angioneurotic edema, imatha kuchepetsa kuchuluka komanso kuuma kwa magawo.
Ntchito odwala hemophilia awo yogwira kukha magazi osakaniza ndi mankhwala ena.
Odwala a Hemophilia omwe ali ndi vuto la factor VIII kapena factor IX pakuchotsa dzino lawo kapena opaleshoni yapakamwa ngati akutulutsa magazi.
