Kufotokozera Kwachidule:
Nambala ya CAS:51322-75-9
Molecular formula:C9H8ClN5S
molecular kulemera:253.71
Chemical kapangidwe:
| Zambiri Zoyambira | |
| Dzina la malonda | Tizanidine |
| Gulu | Pharma kalasi |
| Maonekedwe | Ufa Woyera |
| Kuyesa | 99% |
| Alumali moyo | zaka 2 |
| Kulongedza | 25kg / ng'oma |
| Mkhalidwe | Sungani pa -20 ° C |
Lembani autilaini
Tizanidine ndi yochokera ku imidazoline iwiri ya nayitrogeni heterocyclic pentene. Mapangidwe ake ndi ofanana ndi clonidine. Mu 1987, idalembedwa koyamba ku Finland ngati chapakati adrenalin α2 receptor agonist. Pakadali pano, imagwiritsidwa ntchito ngati chotsitsimula chapakati cha minofu m'chipatala. Ikhoza kugwiritsidwa ntchito pochiza kupweteka kwa minofu, monga matenda a m'chiuno ndi torticollis. Itha kugwiritsidwanso ntchito pochiza ululu wa postoperative, monga disc herniation ndi nyamakazi ya m'chiuno. Zimachokera ku ankylosis ya matenda a ubongo, monga multiple sclerosis, chronic myelopathy, cerebrovascular ngozi ndi zina.
Ntchito
Amagwiritsidwa ntchito kuti achepetse kupsinjika kwa minofu ya chigoba, kupindika kwa minofu ndi myotonia chifukwa cha kuvulala kwaubongo ndi msana, kutulutsa magazi muubongo, encephalitis ndi multiple sclerosis.
Pharmacology
Imasankha kuchepetsa kutulutsidwa kwa ma amino acid osangalatsa kuchokera ku ma interneurons ndikuletsa njira zambiri za synaptic zokhudzana ndi kupsinjika kwa minofu. Izi sizimakhudza kufala kwa neuromuscular. Zimalekerera bwino. Ndiwothandiza pachimake chowawa minofu spasms ndi aakulu ankylosis amachokera ku msana ndi ubongo. Ikhoza kuchepetsa kukana kwa kayendetsedwe kake, kuchepetsa spasticity ndi clonus, ndikuwonjezera mphamvu ya kuyenda mwaufulu.
Ntchito
Wotchedwa Tizanidine, wopangidwa kuti agwiritsidwe ntchito ngati muyeso wamkati wa quantification ya Tizanidine ndi GC- kapena LC-mass spectrometry. Tizanidine atha kugwiritsidwa ntchito pochizira ngati SARS-CoV-2 main protease inhibitor.
Kugwiritsa Ntchito Zachipatala
Tizanidine ndi adrenergic α2 receptor agonist omwe amagwiritsidwa ntchito pochiza matenda aakulu a minofu, monga multiple sclerosis.
Njira yochitira
Tizanidine ndi analogue ya clonidine yopumula kwambiri ya minofu yomwe imavomerezedwa kuti igwiritsidwe ntchito pochepetsa kupsinjika komwe kumakhudzana ndi kuvulala kwaubongo kapena msana. Njira yake yochepetsera spasticity ikuwonetsa kuletsa kwa presynaptic kwa ma motor neurons paαMalo a 2-adrenergic receptor, kuchepetsa kutulutsidwa kwa ma amino acid osangalatsa komanso kulepheretsa njira zothandizira ceruleospinal, motero kumachepetsa kuchepa kwa spasticity. Tizanidine ali ndi kachigawo kakang'ono chabe ka antihypertensive zochita za clonidine, mwina chifukwa cha zochita pagulu la kusankha.α2C-adrenoceptors, omwe amawoneka kuti ali ndi udindo wa analgesic ndi antispasmodic ntchito. imidazolineα2-agonists (20).
