Kufotokozera Kwachidule:
Nambala ya CAS: 55268-74-1
Fomula ya mamolekyulu: C19H24N2O2
kulemera kwa thupi: 312.41
Chemical kapangidwe:
| Zambiri Zoyambira | |
| Dzina la malonda | Praziquantel |
| Gulu | Pharma kalasi |
| Maonekedwe | Ndi woyera kapena pafupifupi woyera crystalline ufa |
| Kuyesa | 99% |
| Alumali moyo | zaka 2 |
| Kulongedza | 25kg / ng'oma |
| Khalidwe | Zosungunuka momasuka mu ethanol kapena dichloromethane. Zosungunuka pang'ono m'madzi |
| Mkhalidwe | Osindikizidwa muumirira, Sungani mufiriji, pansi pa -20°C |
Kufotokozera
Praziquantel (PZQ) ndi chochokera ku isoquinoline chokhala ndi zochitika zambiri zamoyo zomwe zimapezeka mu levo enantiomer. Mankhwalawa alibe ntchito yolimbana ndi nematodes, koma amagwira ntchito kwambiri polimbana ndi cestodes ndi trematodes.
Pharmacology ndi limagwirira ntchito
Praziquantel ndi mankhwala a pyrazinoquinoline omwe adapangidwa kuti azichiza likodzo koma adapezeka kuti ali ndi zochita zambiri za anthelminthic. Praziquantel ndi racemate koma R (+) enantiomer ndi udindo wake antiparasitic ntchito. Imagwira ntchito motsutsana ndi trematodes (mitundu yonse ya Schistosoma pathogenic kwa munthu, Paragonimus westermani, ndi Clonorchis sinensis) ndi cestodes (Taenia saginata, Taenia solium, Hymenolepis nana ndi Diphyllobothrium latum) .
Limagwirira ntchito praziquantel sizidziwika bwino. Schistosomes amamwa mankhwalawa mwachangu. Kumwa mankhwala nthawi yomweyo kumatsatiridwa ndi kuchulukira kwamphamvu kwamphamvu komwe kumapangitsa kuti tetanic contraction ndi vacuolization ya parasite tegument.
Zotsatira za minyewa ya mankhwalawa zimaganiziridwa kuti ndizomwe zimayambitsa kusamuka kwa majeremusi kuchokera ku mitsempha ya mesenteric kupita ku chiwindi mu vivo. Komabe, kusintha kwa chiwindi kwawonetsedwa ndi mankhwala opha likodzo odziwika bwino ndipo mwina sangapereke chidziwitso chatsatanetsatane cha momwe mankhwalawa amagwirira ntchito. Zomwe zapezedwa posachedwa zasonyeza kuti zotsatira za antischistosomal za mankhwalawa zimagwirizana ndi zotsatira zake pa tegument osati pa minofu.
Wina pharmacological zotsatira za mankhwala zikuphatikizapo kuwonjezeka nembanemba permeability kuti cations, makamaka kashiamu.
Komabe, ntchito ya mankhwalawa ku katundu wa anthelminthic ya mankhwala sichidziwika.
Kugwiritsa ntchito
Ndi mtundu wa yotakata sipekitiramu anti-parasitic mankhwala mankhwala. Angagwiritsidwe ntchito pochiza ndi kupewa likodzo, cysticercosis, paragonimiasis, hydatid matenda, fasciolopsiasis, hydatid matenda, ndi matenda nyongolotsi.
Itha kugwiritsidwanso ntchito ngati anthelmintic ndipo imathandiza pochiza nematode zam'mimba za nyama. Ikhoza kusakanikirana mu chakudya kuti igwiritsidwe ntchito.
Mankhwalawa ndi anthelmintic mankhwala othandiza pochiza Schistosoma japonicum, Schistosoma mansoni ndi Schistosoma haematobium, Clonorchis sinensis, Paragonimus westermani, fasciolopsis buski, tapeworms ndi cysticercosis. Ili ndi mphamvu yakupha kwambiri pa nyongolotsi za tapeworm ndipo pakadali pano ndiyothandiza kwambiri pakati pa mankhwala othana ndi likodzo.
Ndi mtundu wa mankhwala anthelmintics omwe amagwiritsidwa ntchito kwambiri pochiza likodzo. Itha kugwiritsidwanso ntchito pochiza Fahrenheit schistosomiasis, taeniasis, paragonimiasis, ndi cysticercosis.
