Kufotokozera Kwachidule:
Nambala ya CAS: 15687-27-1
Mapangidwe a maselo: C13H18O2
Molecular kulemera: 206.28
Kapangidwe ka Chemical:
| Zambiri Zoyambira | |
| Dzina la malonda | Ibuprofen |
| CAS No. | 15687-27-1 |
| Mtundu | Zoyera mpaka zoyera |
| Fomu | Crystalline Powder |
| Kusungunuka | Pafupifupi osasungunuka m'madzi, amasungunuka mwaulere mu acetone, mu methanol ndi mu methylene chloride. Imasungunuka mu njira zochepetsera za alkali hydroxides ndi carbonates. |
| Kusungunuka kwamadzi | osasungunuka |
| Kukhazikika | Wokhazikika. Zoyaka. Zosagwirizana ndi ma oxidizing amphamvu |
| Shelf Life | 2 Ymakutu |
| Phukusi | 25kg / Drum |
Kufotokozera
Ibuprofen ndi wa nonsteroidal odana ndi kutupa analgesic. Ili ndi anti-yotupa, analgesic ndi antipyretic kwenikweni ndi zotsatira zochepa zoyipa. Amagwiritsidwa ntchito kwambiri padziko lonse lapansi, monga mankhwala ogulitsidwa kwambiri padziko lonse lapansi osapereka mankhwala. Iwo, pamodzi ndi aspirin ndi paracetamol amalembedwa ngati mankhwala atatu ofunika kwambiri a antipyretic analgesics. M'dziko lathu, izo zimagwiritsa ntchito ululu kuchepetsa ndi odana ndi misempha, etc. Iwo ali zochepa ntchito pa matenda a chimfine ndi malungo poyerekeza ndi paracetamol ndi aspirin. Pali makampani ambiri opanga mankhwala omwe ali oyenerera kupanga ibuprofen ku China. Koma kuchuluka kwa malonda amsika amsika a ibuprofen adakhala ndi Tianjin Sino-US Company.
Ibuprofen inapezedwa ndi Dr. Stewart Adams (kenako adakhala pulofesa ndipo adagonjetsa Medal of the British Empire) ndi gulu lake kuphatikizapo CoLinBurrows ndi Dr. John Nicholson. Cholinga cha kafukufuku woyamba chinali kupanga "aspirin wapamwamba kwambiri" kuti apeze njira ina yochizira nyamakazi ya nyamakazi yomwe ingafanane ndi ya aspirin koma yokhala ndi zovuta zochepa kwambiri. Kwa mankhwala ena monga phenylbutazone, ali ndi chiopsezo chachikulu choyambitsa adrenal kuponderezedwa ndi zochitika zina zoipa monga zilonda zam'mimba. Adams adaganiza zoyang'ana mankhwala omwe ali ndi vuto la m'mimba, lomwe ndilofunika kwambiri kwa mankhwala onse omwe si a steroidal anti-inflammatory.
Mankhwala a Phenyl acetate adzutsa chidwi cha anthu. Ngakhale ena mwa mankhwalawa apezeka kuti ali pachiwopsezo choyambitsa zilonda potengera mayeso a galu, Adams akudziwa kuti chodabwitsa ichi chingakhale chifukwa cha theka la moyo wautali wa chilolezo chamankhwala. Mu gulu ili la mankhwalawa pali pawiri - ibuprofen, yomwe ili ndi theka la moyo waufupi, wokhala ndi maola awiri okha. Pakati pa mankhwala osankhidwa omwe amasankhidwa, ngakhale kuti si othandiza kwambiri, ndi otetezeka kwambiri. Mu 1964, ibuprofen idakhala njira yodalirika kwambiri yosinthira aspirin.
Zizindikiro
Cholinga chodziwika pakupanga mankhwala opweteka ndi kutupa kwakhala kupangidwa kwa mankhwala omwe amatha kuchiza kutupa, kutentha thupi, ndi kupweteka popanda kusokoneza ntchito zina za thupi. Mankhwala ochepetsa ululu, monga aspirin ndi ibuprofen, amalepheretsa onse a COX-1 ndi COX-2. Kufotokozera kwamankhwala ku COX-1 motsutsana ndi COX-2 kumatsimikizira kuthekera kwa zotsatirapo zoyipa. Mankhwala a COX-1 ali ndi kuthekera kwakukulu kopanga zotsatira zoyipa. Poletsa COX-1, zochotsa ululu zosasankha zimawonjezera mwayi wokhala ndi zotsatirapo zosafunika, makamaka mavuto am'mimba monga zilonda zam'mimba ndi kutuluka kwa m'mimba. COX-2 inhibitors, monga Vioxx ndi Celebrex, amaletsa COX-2 mwa kusankha ndipo samakhudza COX-1 pa mlingo woperekedwa. COX-2 inhibitors amalembedwa kwambiri kuti athetse nyamakazi komanso kuchepetsa ululu. Mu 2004, Food and Drug Administration (FDA) inalengeza kuti chiwopsezo chowonjezereka cha matenda a mtima ndi sitiroko chimagwirizanitsidwa ndi COX-2 inhibitors. Izi zidapangitsa kuti pakhale zilembo zochenjeza ndikuchotsa dala zinthu pamsika ndi opanga mankhwala; mwachitsanzo, Merck adachotsa Vioxx pamsika mu 2004. Ngakhale ibuprofen imalepheretsa onse a COX-1 ndi COX-2, imakhala ndi nthawi zingapo zomwe zimatsutsana ndi COX-2 poyerekeza ndi aspirin, zomwe zimapanga zotsatira zochepa za m'mimba..
