Kufotokozera Kwachidule:
Nambala ya CAS: 38821-53-3
Mapangidwe a maselo: C16H19N3O4S
Kulemera kwa molekyulu: 349.4
Kapangidwe ka Chemical:
| Zambiri Zoyambira | |
| Dzina la malonda | Cefradine |
| Kukhazikika | Kuwala Kumverera |
| Maonekedwe | White ufa |
| Kuyesa | 99% |
| Malo osungunuka | 140-142 C |
| Kulongedza | 5kg; 1kg |
| Malo otentha | 898℃ |
Kufotokozera
Cefradine (yomwe imadziwikanso kuti cephradine), 7--[D-2-amino-2 (1,4cyclohexadien1-yl) acetamido]-3-methyl-8-0x0-5thia-l-azabicyclo[4.2.0] oct-2- ene-2-carboxylic acid monohydrate (111 ndi semisynthetic cephalosporin antibiotic. amagwiritsidwa ntchito pakamwa, intramuscularly, ndi mtsempha. zomangira ziwiri zomwe zimapanga dongosolo lonunkhira pamene cephradine ili ndi zomangira ziwiri mu mphete imodzi Ntchito ya antibacterial ya cephradine ndi yofanana ndi ya cephalexin[1].
Chithunzi 1 kapangidwe ka mankhwala a cefradine;
Cephradine ndi ufa woyera wa crystalline wokhala ndi molekyulu wolemera wa 349.4[2]. Kaphatikizidwe ka cephradine kakambidwa[3]. Cephradine amasungunuka momasuka mu zosungunulira zamadzimadzi. Ndi zwitterion, yomwe ili ndi gulu la alkaline amino ndi gulu la acidic carboxyl. Mu pH ya 3-7, cephradine ilipo ngati mchere wamkati[4]. Cephradine imakhala yokhazikika kwa 24 hr pa 25 ″ mkati mwa pH ya 2-8. Popeza imakhala yokhazikika muzofalitsa za acidic, palibe kutaya pang'ono kwa ntchito m'mimba ya m'mimba; kutayika kosachepera 7% kwanenedwa.[5].
Cephradine imamangidwa mofooka ku mapuloteni a seramu aumunthu. Mankhwalawa anali osakwana 20% omangidwa ku mapuloteni a seramu[4]. Pa seramu ndende ya 10-12 pg/ml, 6% ya mankhwala onse anali mu zovuta zomanga mapuloteni. Phunziro lina[6]anapeza kuti pa chiwerengero cha 10 pg/ml, 28% ya mankhwalawa anali m'mapuloteni; pamagulu okwana 100 pg/ml, 30% ya mankhwalawa anali m'malo omanga mapuloteni. Kafukufukuyu adawonetsanso kuti kuwonjezera kwa seramu ku cephradine kumachepetsa ntchito ya maantibayotiki. Phunziro lina[2]anasonyeza kuti mapuloteni kumanga cephradine zosiyanasiyana 8 mpaka 20%, malinga ndi ndende ya mankhwala. Komabe, kafukufuku wa Gadebusch et al.[5]sanapeze kusintha kwa MIC ya cephradine ku Staphylococcus aureus kapena Escherichia coli pambuyo pa kuwonjezera kwa seramu yaumunthu.
Zizindikiro
Cephradine imagwira ntchito mu m'galasi motsutsana ndi mabakiteriya ambiri omwe ali ndi gram-positive ndi gram-negative, kuphatikizapo tizilombo toyambitsa matenda tomwe timapezeka kuchipatala; chigawocho chasonyezedwa kukhala chokhazikika cha asidi, ndipo kuwonjezeredwa kwa seramu yaumunthu kunali ndi zotsatira zochepa chabe pa chiwerengero chochepa cha inhibitory concentration (MIC) kwa zamoyo zovuta. Ikaperekedwa pakamwa kapena pang'onopang'ono kwa nyama zomwe zili ndi kachilombo koyesa mabakiteriya osiyanasiyana, cephradine imapereka chitetezo chokwanira.[16]. Pochiza matenda opatsirana kwambiri, mayankho okhutiritsa azachipatala ku chithandizo cha cephradine adanenedwa ndi ofufuza angapo.[ 14, 15, 17-19 ].
