Cefoperazone sodium + sulbactam sodium

Kufotokozera:
Cefoperazone sodium + sulbactam sodium (1:1/2:1) ndi parenterally-active, β-lactamase inhibitor yomwe yatulutsidwa posachedwa ngati 1: 1 yosakaniza mankhwala ndi cefoperazone. Monga clavulanic acid, wothandizira woyamba wamtunduwu kuyambitsidwa, sulbactam imakulitsa mphamvu ya maantibayotiki a β-lactam motsutsana ndi zovuta zosamva.
Kagwiritsidwe:
Ndi semisynthetic β-lactamase inhibitor. Amagwiritsidwa ntchito limodzi ndi maantibayotiki a β-lactam ngati antibacterial.
Cefoperazone sodium mchere ndi cephalosporin antibiotic pofuna kuletsa rMrp2-mediated [3H]E217βG kutenga ndi IC50 ya 199 μM. Zolinga: Antibacterial Cefoperazone ndi wosabala, semisynthetic, yotakata sipekitiramu, parenteral cephalosporin mankhwala kwa mtsempha kapena intramuscular. Pambuyo polowetsedwa m'mitsempha ya 2 g ya cefoperazone, milingo ya seramu idachokera ku 202μg/mL mpaka 375 μg/mL kutengera nthawi yamankhwala. Pambuyo jekeseni mu mnofu wa 2 g wa Cefoperazone, chiwerengero chapamwamba kwambiri cha seramu ndi 111 μg/mL pa maola 1.5. Pamaola 12 mutatha kumwa, kuchuluka kwa seramu kumakhalabe 2 mpaka 4 μg/mL. Cefoperazone imamangidwa 90% ku mapuloteni a seramu.