Kufotokozera Kwachidule:
Nambala ya CAS:590-63-6
Molecular formula:C7H17ClN2O2
molecular kulemera:196.68
Chemical kapangidwe:
| Zambiri Zoyambira | |
| Dzina la malonda | Bethanechol |
| Gulu | Pharma kalasi |
| Maonekedwe | ufa woyera |
| Kuyesa | 95% |
| Alumali moyo | zaka 2 |
| Kulongedza | 25kg / ng'oma |
| Mkhalidwe | Malo Ozizira ndi Owuma |
Kufotokozera
Bethanechol ndi ester yopangidwa mwadongosolo komanso pharmacologically yokhudzana ndi acetylcholine. Katswiri wa muscarinic pang'onopang'ono wa hydrolyzed wopanda zotsatira za nicotinic, bethanechol nthawi zambiri amagwiritsidwa ntchito kukulitsa kamvekedwe ka minofu yosalala, monga momwe zilili mu thirakiti la GI pambuyo pa opaleshoni ya m'mimba kapena posungira mkodzo popanda chopinga. Zitha kuyambitsa hypotension, kusintha kwa mtima, komanso kupuma movutikira.
Bethanechol ndi agonist wa muscarinic acetylcholine receptors ndi IC50 values of 1,837, 25, 631, 317, and 393 μM for M1-5, motero, mu radioligand kumanga assay pogwiritsa ntchito CHO maselo kufotokoza zolandilira anthu. Imalepheretsa kuwonjezeka kwa M2-mediated mu cyclic AMP yopangidwa ndi isoproterenol m'matumbo ang'onoang'ono a Guinea (IC50 = 127 μM). Bethanechol imawonjezera kamvekedwe ka basal kamvekedwe ka nkhumba yaing'ono intravesical ureter (EC50 = 4.27 μM). Zimapangitsanso kuti madzi asungunuke mu ileamu, duodenum, ndi jejunum ya makoswe otsekemera pamene akugwiritsidwa ntchito pa mlingo wa 60 μg / kg. Mapangidwe okhala ndi bethanechol akhala akugwiritsidwa ntchito kukulitsa kukodza ndikuwongolera kamvekedwe ka minofu m'matumbo am'mimba.
Kugwiritsa Ntchito Zachipatala
Kugwiritsa ntchito kwakukulu kwa bethanechol chloride ndikuchepetsa kutsekeka kwa mkodzo komanso kupweteka kwam'mimba pambuyo pa opaleshoni. Mankhwalawa amagwiritsidwa ntchito pakamwa komanso jekeseni wa subcutaneous. Sitiyenera kuperekedwa ndi intramuscular kapena intravenousjekeseni chifukwa cha kuopsa kwa cholinergic overstimulation komanso kutayika kosankha. Kuwongolera koyenera kwa mankhwalawa kumalumikizidwa ndi kawopsedwe kakang'ono ndipo palibe zovuta zoyipa. Bethanechol kolorayidi ayenera kugwiritsidwa ntchito mosamala odwala mphumu; Akagwiritsidwa ntchito pochiza glaucoma, amatulutsa mutu wakutsogolo chifukwa cha kupindika kwa sphinctermucle m'maso komanso kuphatikizika kwa minofu ya ciliary. Kutalika kwake ndi 1 ora.
Mankhwala a Chowona Zanyama ndi Chithandizo
Muzachinyama, bethanechol imagwiritsidwa ntchito makamaka kulimbikitsa kukokoloka kwa chikhodzodzo mwa nyama zazing'ono. Itha kugwiritsidwanso ntchito ngati esophageal kapena general GI stimulant, ngakhale metoclopramide ndi/kapena neostigmine adayilowa m'malo mwa izi.
