Kufotokozera Kwachidule:
Nambala ya CAS: 7177-48-2
Molecular formula: C16H25N3O7S
molekyulu kulemera: 403.45
Chemical kapangidwe:
| Zambiri Zoyambira | |
| Dzina la malonda | Ampicillin |
| Gulu | Gulu la Pharmaceutical |
| Maonekedwe | White kapena pafupifupi woyera, crystalline ufa |
| Kuyesa | |
| Alumali moyo | zaka 2 |
| Kulongedza | 25kg / ng'oma |
| Mkhalidwe | kusungidwa pa malo ozizira ndi ouma |
Kufotokozera
Monga gulu la penicillin la maantibayotiki a beta-lactam, Ampicillin ndiye penicillin yoyamba yotakata, yomwe imakhala ndi zochita zolimbana ndi mabakiteriya a Gram-positive ndi gram-negative aerobic ndi anaerobic, omwe amagwiritsidwa ntchito popewa komanso kuchiza matenda obwera chifukwa cha mabakiteriya amkodzo, mkodzo. thirakiti, khutu lapakati, zilonda zam'mimba, m'mimba ndi matumbo, chikhodzodzo, impso, ndi zina zotero chifukwa cha mabakiteriya omwe amatha kutenga kachilomboka. Amagwiritsidwanso ntchito pochiza chinzonono chosavuta, meningitis, endocarditis salmonellosis, ndi matenda ena oopsa kudzera m'kamwa, jekeseni wa muscular kapena kudzera m'mitsempha. Monga maantibayotiki onse, sizothandiza pochiza matenda a virus.
Ampicillin amagwira ntchito popha mabakiteriya kapena kuwalepheretsa kukula kwawo. Pambuyo polowera mabakiteriya a gram-positive ndi gram-negative, imakhala ngati inhibitor yosasinthika ya enzyme transpeptidase yofunikira ndi mabakiteriya kuti apange khoma la cell, zomwe zimabweretsa kuletsa kwa kaphatikizidwe ka cell khoma ndipo pamapeto pake kumabweretsa cell lysis.
Antimicrobial ntchito
Ampicillin ndiwocheperako pang'ono poyerekeza ndi benzylpenicillin motsutsana ndi mabakiteriya ambiri a Gram-positive koma amagwira ntchito kwambiri polimbana ndi E. faecalis. MRSA ndi zovuta za Str. pneumoniae ndi kuchepa kwa chiwopsezo cha benzylpenicillin ndi kugonjetsedwa. Ambiri gulu D streptococci, anaerobic Gram-positive cocci ndi bacilli, kuphatikizapo L. monocytogenes, Actinomyces spp. ndi Arachnia spp., ali pachiwopsezo. Mycobacteria ndi nocardia zimagonjetsedwa.
Ampicillin ali ndi zochita zofanana ndi benzylpenicillin motsutsana ndi N. gonorrhoeae, N. meningitidis ndi Mor. matenda a catarrhalis. Imakhala yogwira ntchito 2-8 kuposa benzylpenicillin motsutsana ndi H. influenzae ndi Enterobacteriaceae ambiri, koma mitundu yotulutsa β-lactamase imagonjetsedwa. Pseudomonas spp. amalimbana, koma Bordetella, Brucella, Legionella ndi Campylobacter spp. nthawi zambiri amakhudzidwa. Ma anaerobes ena a Gram-negative monga Prevotella melaninogenica ndi Fusobacterium spp. amatengeka, koma B. fragilis ndi kugonjetsedwa, monga mycoplasmas ndi rickettsiae.
Ntchito yolimbana ndi mitundu ya mamolekyulu A β-lactamase yotulutsa staphylococci, gonococci, H. influenzae, Mor. catarrhalis, ena Enterobacteriaceae ndi B. fragilis amalimbikitsidwa ndi kukhalapo kwa β-lactamase inhibitors, makamaka clavulanic acid.
Ntchito yake ya bactericidal ikufanana ndi ya benzylpenicillin. Kugwirizana kwa mabakiteriya kumachitika ndi aminoglycosides motsutsana ndi E. faecalis ndi enterobacteria ambiri, komanso mecillinam motsutsana ndi ma enterobacteria angapo osamva ampicillin.
